Elevated Nuclear PHGDH Synergistically Functions with cMyc to Reshape the Immune Microenvironment of Liver Cancer

Abstract Herein, we observed that nuclear localization of phosphoglycerate dehydrogenase (PHGDH) is associated with poor prognosis in liver cancer, and Phgdh is required for liver cancer progression in a mouse model. Unexpectedly, impairment of Phgdh enzyme activity exerts a slight effect in a liver...

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Bibliographic Details

Published in:	Advanced Science
Main Authors:	Hongwen Zhu, Hua Yu, Hu Zhou, Wencheng Zhu, Xiongjun Wang
Format:	Article
Language:	English
Published:	Wiley 2023-06-01
Subjects:	cMyc CXCL1/IL8 liver cancer neutrophil nuclear PHGDH
Online Access:	https://doi.org/10.1002/advs.202205818