Weighted gene co-expression network analysis identifies dysregulated B-cell receptor signaling pathway and novel genes in pulmonary arterial hypertension

BackgroundPulmonary arterial hypertension (PAH) is a devastating cardio-pulmonary vascular disease in which chronic elevated pulmonary arterial pressure and pulmonary vascular remodeling lead to right ventricular failure and premature death. However, the exact molecular mechanism causing PAH remains...

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Bibliographic Details

Published in:	Frontiers in Cardiovascular Medicine
Main Authors:	Yuanrong Chen, Chaoling Wu, Xiaoping Wang, Xufeng Zhou, Kunpeng Kang, Zuofeng Cao, Yihong Yang, Yiming Zhong, Genfa Xiao
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2022-10-01
Subjects:	pulmonary arterial hypertension B-cell receptor signaling pathway weighted gene co-expression network analysis humoral immunity hub genes
Online Access:	https://www.frontiersin.org/articles/10.3389/fcvm.2022.909399/full