Upregulation of tissue factor by activated Stat3 contributes to malignant pleural effusion generation via enhancing tumor metastasis and vascular permeability in lung adenocarcinoma.

Malignant pleural effusion (MPE) is a poor prognostic sign for patients with lung cancer. Tissue factor (TF) is a coagulation factor that participates in angiogenesis and vascular permeability and is abundant in MPE. We previously demonstrated that autocrine IL-6-activated Stat3 contributes to tumor...

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Bibliographic Details

Published in:	PLoS ONE
Main Authors:	Hsuan-Heng Yeh, Wen-Tsan Chang, Kuang-Chu Lu, Wu-Wei Lai, Hsiao-Sheng Liu, Wu-Chou Su
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2013-01-01
Online Access:	http://europepmc.org/articles/PMC3785526?pdf=render