Hepatitis C Virus Down-Regulates the Expression of Ribonucleotide Reductases to Promote Its Replication

Ribonucleotide reductases (RRs or RNRs) catalyze the reduction of the OH group on the 2nd carbon of ribose, reducing four ribonucleotides (NTPs) to the corresponding deoxyribonucleotides (dNTPs) to promote DNA synthesis. Large DNA viruses, such as herpesviruses and poxviruses, could benefit their re...

Full description

Bibliographic Details

Published in:	Pathogens
Main Authors:	Chee-Hing Yang, Cheng-Hao Wu, Shih-Yen Lo, Ahai-Chang Lua, Yu-Ru Chan, Hui-Chun Li
Format:	Article
Language:	English
Published:	MDPI AG 2023-06-01
Subjects:	hepatitis C virus ribonucleotide reductase NTP/dNTP ratio Didox Trimidox hydroxyurea
Online Access:	https://www.mdpi.com/2076-0817/12/7/892