The neuroprotective effect of nicotine in Parkinson’s disease models is associated with inhibiting PARP-1 and caspase-3 cleavage

Clinical evidence points to neuroprotective effects of smoking in Parkinson’s disease (PD), but the molecular mechanisms remain unclear. We investigated the pharmacological pathways involved in these neuroprotective effects, which could provide novel ideas for developing targeted neuroprotective tre...

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Bibliographic Details

Published in:	PeerJ
Main Authors:	Justin Y.D. Lu, Ping Su, James E.M. Barber, Joanne E. Nash, Anh D. Le, Fang Liu, Albert H.C. Wong
Format:	Article
Language:	English
Published:	PeerJ Inc. 2017-10-01
Subjects:	Parkinson’s disease Nicotine Smoking MPP+ 6-OHDA Mouse
Online Access:	https://peerj.com/articles/3933.pdf