Synthesis of 5′-GalNAc-Conjugated Oligonucleotides: A Comparison of Solid and Solution-Phase Conjugation Strategies

Antisense oligonucleotides (ASOs) conjugated to triantennary N-acetyl galactosamine (GalNAc) ligands represent an emerging approach to antisense therapy. Our current generation of GalNAc-ASO conjugates link the GalNAc to the 5′-terminus of the ASO. The conjugation reaction can be accomplished using...

詳細記述

書誌詳細

出版年:	Molecules
主要な著者:	Isaiah Cedillo, Dana Chreng, Elyse Engle, Lijian Chen, Andrew K. McPherson, Andrew A. Rodriguez
フォーマット:	論文
言語:	英語
出版事項:	MDPI AG 2017-08-01
主題:	oligonucleotide GalNAc conjugate
オンライン･アクセス:	https://www.mdpi.com/1420-3049/22/8/1356