Synthesis of 5′-GalNAc-Conjugated Oligonucleotides: A Comparison of Solid and Solution-Phase Conjugation Strategies

Antisense oligonucleotides (ASOs) conjugated to triantennary N-acetyl galactosamine (GalNAc) ligands represent an emerging approach to antisense therapy. Our current generation of GalNAc-ASO conjugates link the GalNAc to the 5′-terminus of the ASO. The conjugation reaction can be accomplished using...

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Bibliographic Details

Published in:	Molecules
Main Authors:	Isaiah Cedillo, Dana Chreng, Elyse Engle, Lijian Chen, Andrew K. McPherson, Andrew A. Rodriguez
Format:	Article
Language:	English
Published:	MDPI AG 2017-08-01
Subjects:	oligonucleotide GalNAc conjugate
Online Access:	https://www.mdpi.com/1420-3049/22/8/1356