PET-based radiomics visualizes tumor-infiltrating CD8 T cell exhaustion to optimize radiotherapy/immunotherapy combination in mouse models of lung cancer

Abstract Background Cumulative preclinical and clinical evidences showed radiotherapy might augment systemic antitumoral responses to immunotherapy for metastatic non-small cell lung cancer, but the optimal timing of combination is still unclear. The overall infiltration and exhausted subpopulations...

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Bibliographic Details

Published in:	Biomarker Research
Main Authors:	Ying Zhang, Hui-Hui Hu, Shi-Hong Zhou, Wu-Yan Xia, Yan Zhang, Jian-Ping Zhang, Xiao-Long Fu, Wen Yu
Format:	Article
Language:	English
Published:	BMC 2023-01-01
Subjects:	Radiotherapy Immunotherapy Tumor microenvironment CD8+ T cell exhaustion Radiomics
Online Access:	https://doi.org/10.1186/s40364-023-00454-z