Early plasma ceramide and sphingomyelin levels reflect APOE genotype but not familial Alzheimer's disease gene mutations in female 5xFAD mice, with brain-region specific sphingolipid alterations

Pathophysiological changes associated with Alzheimer's disease (AD) begin decades before dementia onset, with age and APOE ε4 genotype as major risk factors [1–4]. Primary risk factors for developing AD include aging and number of copies of the apolipoprotein E (APOE) ε4 allele. Altered sphingo...

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Bibliographic Details

Published in:	Neurobiology of Disease
Main Authors:	Daan van Kruining, Mario Losen, Jonas Dehairs, Johannes V. Swinnen, Etienne Waelkens, Maarten Honing, Pilar Martinez-Martinez
Format:	Article
Language:	English
Published:	Elsevier 2025-06-01
Subjects:	Alzheimer's disease Sphingolipid metabolism APOE genotype Liquid chromatography-tandem mass spectrometry (LC-MS/MS)
Online Access:	http://www.sciencedirect.com/science/article/pii/S0969996125001391