SCFβ-TRCP E3 ubiquitin ligase targets the tumor suppressor ZNRF3 for ubiquitination and degradation

Abstract Wnt signaling has emerged as a major regulator of tissue development by governing the self-renewal and maintenance of stem cells in most tissue types. As a key upstream regulator of the Wnt pathway, the transmembrane E3 ligase ZNRF3 has recently been established to play a role in negative r...

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Bibliographic Details

Published in:	Protein & Cell
Main Authors:	Yanpeng Ci, Xiaoning Li, Maorong Chen, Jiateng Zhong, Brian J. North, Hiroyuki Inuzuka, Xi He, Yu Li, Jianping Guo, Xiangpeng Dai
Format:	Article
Language:	English
Published:	Oxford University Press 2018-03-01
Subjects:	ZNRF3 β-TRCP Wnt ubiquitination CKI
Online Access:	http://link.springer.com/article/10.1007/s13238-018-0510-2