Etomoxir repurposed as a promiscuous fatty acid mimetic chemoproteomic probe

Summary: Etomoxir has been used for decades as a popular small molecule inhibitor of carnitine palmitoyltransferase I, Cpt1, to block mitochondrial fatty acid β-oxidation. To test the specificity of etomoxir, we generated click chemistry–enabled reagents to label etomoxir binding proteins in situ. E...

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Bibliographic Details

Published in:	iScience
Main Authors:	Joseph Choi, Danielle M. Smith, Ye Jin Lee, Danfeng Cai, Mohammad J. Hossain, Tamara J. O’Connor, Pragney Deme, Norman J. Haughey, Susanna Scafidi, Ryan C. Riddle, Michael J. Wolfgang
Format:	Article
Language:	English
Published:	Elsevier 2024-09-01
Subjects:	Biochemistry Chemical compound Enzymology Molecular biology Molecular interaction
Online Access:	http://www.sciencedirect.com/science/article/pii/S2589004224018674