Designing Cyclic-Constrained Peptides to Inhibit Human Phosphoglycerate Dehydrogenase

Although loop epitopes at protein-protein binding interfaces often play key roles in mediating oligomer formation and interaction specificity, their binding sites are underexplored as drug targets owing to their high flexibility, relatively few hot spots, and solvent accessibility. Prior attempts to...

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Bibliographic Details

Published in:	Molecules
Main Authors:	Xiaoyu Qing, Qian Wang, Hanyu Xu, Pei Liu, Luhua Lai
Format:	Article
Language:	English
Published:	MDPI AG 2023-09-01
Subjects:	loop epitopes cyclic-constrained peptides obligate homo-oligomers protein-protein modulators structure-based peptide design and optimization
Online Access:	https://www.mdpi.com/1420-3049/28/17/6430