Pathological Tau From Alzheimer’s Brain Induces Site-Specific Hyperphosphorylation and SDS- and Reducing Agent-Resistant Aggregation of Tau in vivo

Neurofibrillary tangles (NFTs) made up of hyperphosphorylated tau are a histopathological hallmark of Alzheimer’s disease (AD) and related tauopathies. Hyperphosphorylation of tau is responsible for its loss of normal physiological function, gain of toxicity and its aggregation to form NFTs. Injecti...

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Bibliographic Details

Published in:	Frontiers in Aging Neuroscience
Main Authors:	Jin Miao, Ruirui Shi, Longfei Li, Feng Chen, Yan Zhou, Yunn Chyn Tung, Wen Hu, Cheng-Xin Gong, Khalid Iqbal, Fei Liu
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2019-03-01
Subjects:	Alzheimer’s disease AD P-tau hyperphosphorylation of tau tau pathology propagation of tau pathology
Online Access:	https://www.frontiersin.org/article/10.3389/fnagi.2019.00034/full