The potent activation of Ca2+-activated K+ current by NVP-AUY922 in the human pancreatic duct cell line (PANC-1) possibly independent of heat shock protein 90 inhibition

NVP-AUY922 (AUY) is a potent inhibitor of heat shock protein 90 (HSP90). Whether this compound can exert additional effects on membrane ion channels remains elusive. We investigated the effect of AUY on ion currents in human pancreatic duct epithelial cells (PDECs), including PANC-1 and MIA PaCa-2....

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Bibliographic Details

Published in:	Journal of Pharmacological Sciences
Main Authors:	Nai-Jung Chiang, Sheng-Nan Wu, Li-Tzong Chen
Format:	Article
Language:	English
Published:	Elsevier 2015-04-01
Subjects:	AUY922 Ca2+-activated K+ current Large-conductance Ca2+-activated K+ channel Heat shock protein 90 Pancreatic duct epithelial cells
Online Access:	http://www.sciencedirect.com/science/article/pii/S1347861315000420