MyD88 orchestrates fatty acid metabolism in tumor-associated macrophages and non-alcoholic fatty liver disease-related hepatocarcinogenesis

IntroductionNon-alcoholic fatty liver disease (NAFLD) is a growing cause of cirrhosis and hepatocellular carcinoma (HCC). Toll-like receptors (TLRs) and their adapter protein, myeloid differentiation factor 88 (MyD88), are activated in NAFLD and contribute to its development. However, the specific r...

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Bibliographic Details

Published in:	Frontiers in Immunology
Main Authors:	Haiqiang Chen, Xuanxuan Yan, Zuyin Li, Zhenzhong Deng, Jianchun Gu, Fanxin Zeng, Zhao Li, Jinhua Zhang
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-09-01
Subjects:	macrophage MyD88 NAFLD HCC SREBP1
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2025.1589255/full