Clinical study of PLA2R epitope spreading for predicting proteinuria remission in primary membranous nephropathy

IntroductionM-type phospholipase A2 receptor (PLA2R) is the predominant autoantigen in primary membranous nephropathy (PMN), accounting for approximately 70%–80% of cases. Circulating anti-PLA2R IgG is a widely used biomarker to monitor disease activity and treatment. In recent years, antibodies tar...

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Bibliographic Details

Published in:	Frontiers in Immunology
Main Authors:	Xueyang Cheng, Meiyi Zhou, Caimei Chen, Jing Xue, Bin Liu, Zhijian Zhang, Xiran Zhang, Leting Zhou, Ting Cai, Biao Huang, Yi Zhang, Liang Wang, Xiaobin Liu
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-10-01
Subjects:	primary membranous nephropathy PLA2R epitope spreading rituximab anti-rituximab antibody
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2025.1685738/full