Chemical Inhibitors of Dynamin Exert Differential Effects in VEGF Signaling

VEGFR2 is the main receptor and mediator of the vasculogenic and angiogenic activity of VEGF. Activated VEGFR2 internalizes through clathrin-mediated endocytosis and macropinocytosis. As dynamin is a key regulator of the clathrin pathway, chemical inhibitors of dynamin are commonly used to assess th...

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Bibliographic Details
Published in:Cells
Main Authors: Dimitris Basagiannis, Sofia Zografou, Evangeli Goula, Despoina Gkeka, Evangelos Kolettas, Savvas Christoforidis
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Subjects:
cell signaling
endocytosis
vesicular trafficking
dynamin
inhibitors
endothelial cell biology
Online Access:https://www.mdpi.com/2073-4409/10/5/997

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https://www.mdpi.com/2073-4409/10/5/997

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