Insight in HIV Integration Site Selection Provides a Block-and-Lock Strategy for a Functional Cure of HIV Infection

Despite significant improvements in therapy, the HIV/AIDS pandemic remains an important threat to public health. Current treatments fail to eradicate HIV as proviral DNA persists in long-living cellular reservoirs, leading to viral rebound whenever treatment is discontinued. Hence, a better understa...

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Bibliographic Details

Published in:	Viruses
Main Authors:	Zeger Debyser, Gerlinde Vansant, Anne Bruggemans, Julie Janssens, Frauke Christ
Format:	Article
Language:	English
Published:	MDPI AG 2018-12-01
Subjects:	human immunodeficiency virus integrase integration site selection LEDGF/p75 HRP-2 LEDGIN block-and-lock HIV cure
Online Access:	http://www.mdpi.com/1999-4915/11/1/12