Executioner caspases restrict mitochondrial RNA-driven Type I IFN induction during chemotherapy-induced apoptosis

During apoptosis, mitochondrial outer membrane permeabilization results in cytosolic mitochondrial RNA (mtRNA). Here, the authors demonstrate that caspase-3/7 inhibition promotes a cytosolic mtRNA-driven Type I interferon response via MDA5/MAVS/IRF3, increasing the immunogenicity of chemotherapy-ind...

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Bibliographic Details

Published in:	Nature Communications
Main Authors:	Shane T. Killarney, Rachel Washart, Ryan S. Soderquist, Jacob P. Hoj, Jamie Lebhar, Kevin H. Lin, Kris C. Wood
Format:	Article
Language:	English
Published:	Nature Portfolio 2023-03-01
Online Access:	https://doi.org/10.1038/s41467-023-37146-z