Differences in human IgG1 and IgG4 S228P monoclonal antibodies viscosity and self-interactions: Experimental assessment and computational predictions of domain interactions

Human/humanized IgG4 antibodies have reduced effector function relative to IgG1 antibodies, which is desirable for certain therapeutic purposes. However, the developability and biophysical properties for IgG4 antibodies are not well understood. This work focuses on the head-to-head comparison of key...

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Bibliographic Details

Published in:	mAbs
Main Authors:	Pin-Kuang Lai, Gaurav Ghag, Yao Yu, Veronica Juan, Laurence Fayadat-Dilman, Bernhardt L. Trout
Format:	Article
Language:	English
Published:	Taylor & Francis Group 2021-01-01
Subjects:	Monoclonal antibody self-interaction monoclonal antibody viscosity diffusion interaction parameter IgG1 IgG4 S228P IgG4P
Online Access:	https://www.tandfonline.com/doi/10.1080/19420862.2021.1991256