Novel Artificial 5′UTR Increase Modified mRNA Translation When Injected into Mouse Heart

<b>Background/Objectives:</b> Modified messenger RNA (modRNA) is a promising gene delivery method used to upregulate genes in cardiac tissue, with applications in both clinical and preclinical settings to prevent cardiac remodeling after ischemic injury. The 5′ untranslated region (5′UTR...

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Bibliographic Details

Published in:	Pharmaceutics
Main Authors:	Ann Anu Kurian, Matteo Ghiringhelli, Eyal Shalom, Gayatri Mainkar, Magdalena M. Żak, Matthew Adjmi, Jeffrey Downey, Seonghun Yoon, Nicole Dubois, Filip K. Swirski, Lior Zangi
Format:	Article
Language:	English
Published:	MDPI AG 2025-04-01
Subjects:	modified RNA (modRNA) 5′ untranslated region cardiac gene therapy translation efficiency synthetic RNA motif
Online Access:	https://www.mdpi.com/1999-4923/17/4/490