Anterior gradient 2 induces resistance to sorafenib via endoplasmic reticulum stress regulation in hepatocellular carcinoma

Abstract Background Hepatocellular carcinoma (HCC) accounts for almost 80% of all liver cancer cases and is the sixth most common cancer and the second most common cause of cancer-related death worldwide. The survival rate of sorafenib-treated advanced HCC patients is still unsatisfactory. Unfortuna...

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Bibliographic Details

Published in:	Cancer Cell International
Main Authors:	Hung-Wen Tsai, Yi-Li Chen, Chun-I Wang, Ching‑Chuan Hsieh, Yang-Hsiang Lin, Pei-Ming Chu, Yuh-Harn Wu, Yi-Ching Huang, Cheng-Yi Chen
Format:	Article
Language:	English
Published:	BMC 2023-03-01
Subjects:	Hepatocellular carcinoma Anterior gradient 2 Sorafenib Resistance Cancer progression ER stress
Online Access:	https://doi.org/10.1186/s12935-023-02879-w