A variant form of receptor activator of nuclear factor-κB functions as an osteoprotegerin mimic in bone and cardiac development

Abstract Bone remodeling is tightly regulated by the RANK-RANKL-OPG axis to maintain skeletal integrity. We previously identified a RANK splicing variant, vRANK, which encodes a truncated protein that inhibits osteoclastogenesis and promotes apoptosis. This study examined the regulatory mechanisms o...

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Bibliographic Details

Published in:	Scientific Reports
Main Authors:	Riko Kitazawa, Ryuma Haraguchi, Sohei Kitazawa
Format:	Article
Language:	English
Published:	Nature Portfolio 2025-07-01
Subjects:	RANK Osteoclasts Bone Heart Sam68
Online Access:	https://doi.org/10.1038/s41598-025-13314-7