Network-based modelling of mechano-inflammatory chondrocyte regulation in early osteoarthritis

Osteoarthritis (OA) is a debilitating joint disease characterized by articular cartilage degradation, inflammation and pain. An extensive range of in vivo and in vitro studies evidences that mechanical loads induce changes in chondrocyte gene expression, through a process known as mechanotransductio...

Full description

Bibliographic Details

Published in:	Frontiers in Bioengineering and Biotechnology
Main Authors:	Maria Segarra-Queralt, Gemma Piella, Jérôme Noailly
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2023-02-01
Subjects:	mechanobiology mechanotransduction chondrocyte network-based model osteoarthritis systems biology
Online Access:	https://www.frontiersin.org/articles/10.3389/fbioe.2023.1006066/full