HIF-1 regulates mitochondrial function in bone marrow-derived macrophages but not in tissue-resident alveolar macrophages

Abstract HIF-1α plays a critical role in shaping macrophage phenotype and effector function. We have previously shown that tissue-resident alveolar macrophages (TR-AMs) have extremely low glycolytic capacity at steady-state but can shift toward glycolysis under hypoxic conditions. Here, we generated...

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Bibliographic Details

Published in:	Scientific Reports
Main Authors:	Parker S. Woods, Rengül Cetin-Atalay, Angelo Y. Meliton, Kaitlyn A. Sun, Obada R. Shamaa, Kun Woo D. Shin, Yufeng Tian, Benjamin Haugen, Robert B. Hamanaka, Gökhan M. Mutlu
Format:	Article
Language:	English
Published:	Nature Portfolio 2025-04-01
Subjects:	Alveolar macrophage Bone marrow-derived macrophage HIF-1α Metabolism Mitochondria Inflammation
Online Access:	https://doi.org/10.1038/s41598-025-95962-3