Design, synthesis, and evaluation of Bothrops venom serine protease peptidic inhibitors

Abstract Background: In Central and South America, snakebite envenomation is mainly caused by Bothrops spp. snakes, whose venoms feature significant biochemical richness, including serine proteases. The available bothropic antivenoms are efficient in avoiding fatalities, but do not completely neutr...

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Bibliographic Details

Published in:	Journal of Venomous Animals and Toxins including Tropical Diseases
Main Authors:	Gloria Maria da Silva, Daniel Henrique Berto de Souza, Karoline B. Waitman, Matteo Celano Ebram, Melissa R. Fessel, Iuliu Cezar Zainescu, Fernanda C. Portaro, Montse Heras, Sonia A. de Andrade
Format:	Article
Language:	English
Published:	SciELO 2021-01-01
Subjects:	Peptides Snake venom Serine protease Disease Hemostasis
Online Access:	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992021000100302&tlng=en