Modulation of γ-Secretase Activity by a Carborane-Based Flurbiprofen Analogue

All over the world, societies are facing rapidly aging populations combined with a growing number of patients suffering from Alzheimer’s disease (AD). One focus in pharmaceutical research to address this issue is on the reduction of the longer amyloid-β (Aβ) fragments in the brain by modulation of γ...

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Bibliographic Details

Published in:	Molecules
Main Authors:	Stefan Saretz, Gabriele Basset, Liridona Useini, Markus Laube, Jens Pietzsch, Dijana Drača, Danijela Maksimović-Ivanić, Johannes Trambauer, Harald Steiner, Evamarie Hey-Hawkins
Format:	Article
Language:	English
Published:	MDPI AG 2021-05-01
Subjects:	Alzheimer carborane flurbiprofen γ-secretase modulator (GSM) small molecule amyloid-β (Aβ) peptide
Online Access:	https://www.mdpi.com/1420-3049/26/10/2843