MEK-inhibitor-mediated rescue of skeletal myopathy caused by activating Hras mutation in a Costello syndrome mouse model

Costello syndrome (CS) is a congenital disorder caused by heterozygous activating germline HRAS mutations in the canonical Ras/mitogen-activated protein kinase (Ras/MAPK) pathway. CS is one of the RASopathies, a large group of syndromes caused by mutations within various components of the Ras/MAPK p...

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Bibliographic Details
Published in:Disease Models & Mechanisms
Main Authors: William E. Tidyman, Alice F. Goodwin, Yoshiko Maeda, Ophir D. Klein, Katherine A. Rauen
Format: Article
Language:English
Published: The Company of Biologists 2022-02-01
Subjects:
costello syndrome
hypotonia
mek inhibitor
myogenesis
rasopathies
ras/mapk
Online Access:http://dmm.biologists.org/content/15/2/dmm049166

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http://dmm.biologists.org/content/15/2/dmm049166

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