Interactions of Therapeutic Antibodies With Presynaptically‐Released Misfolded Proteins in Neurodegenerative Diseases. A Spatial Monte‐Carlo Simulation Study

ABSTRACT The spatial progression hypothesis of misfolded tau and alpha‐synuclein proteins in Alzheimer's and Parkinson's Disease proposes the release of proteins from a presynaptic membrane followed by diffusion over the synaptic cleft and uptake by the postsynaptic membrane in the afferen...

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Bibliographic Details

Published in:	CPT: Pharmacometrics & Systems Pharmacology
Main Authors:	Jamie Goff, Maryam Khalifa, Shaina M. Short, Piet H. van derGraaf, Hugo Geerts
Format:	Article
Language:	English
Published:	Wiley 2025-07-01
Subjects:	Alzheimer's disease antibody‐target interaction neuronal synapse spatial trajectories
Online Access:	https://doi.org/10.1002/psp4.70035