Cpd-42 protects against calcium oxalate nephrocalcinosis-induced renal injury and inflammation by targeting RIPK3-mediated necroptosis

Calcium oxalate (CaOx) crystals, as the predominant component of human kidney stones, can trigger excessive cell death and inflammation of renal tubular epithelial cells, involved in the pathogenesis of nephrocalcinosis. Necroptosis mediated by receptor-interacting protein kinase 3 (RIPK3) serves a...

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الحاوية / القاعدة:	Frontiers in Pharmacology
المؤلفون الرئيسيون:	Bingbing Hou, Mingming Liu, Yang Chen, Weijian Ni, Xiaoguo Suo, Yuexian Xu, Qiushi He, Xiaoming Meng, Zongyao Hao
التنسيق:	مقال
اللغة:	الإنجليزية
منشور في:	Frontiers Media S.A. 2022-11-01
الموضوعات:	calcium oxalate nephrocalcinosis inflammation necroptosis ripk3 compound 42
الوصول للمادة أونلاين:	https://www.frontiersin.org/articles/10.3389/fphar.2022.1041117/full