Cpd-42 protects against calcium oxalate nephrocalcinosis-induced renal injury and inflammation by targeting RIPK3-mediated necroptosis

Calcium oxalate (CaOx) crystals, as the predominant component of human kidney stones, can trigger excessive cell death and inflammation of renal tubular epithelial cells, involved in the pathogenesis of nephrocalcinosis. Necroptosis mediated by receptor-interacting protein kinase 3 (RIPK3) serves a...

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Bibliographic Details
Published in:	Frontiers in Pharmacology
Main Authors:	Bingbing Hou, Mingming Liu, Yang Chen, Weijian Ni, Xiaoguo Suo, Yuexian Xu, Qiushi He, Xiaoming Meng, Zongyao Hao
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2022-11-01
Subjects:	calcium oxalate nephrocalcinosis inflammation necroptosis ripk3 compound 42
Online Access:	https://www.frontiersin.org/articles/10.3389/fphar.2022.1041117/full

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