Identifying propionate metabolism-related genes as biomarkers of sepsis development and therapeutic targets

Abstract The treatment of sepsis is challenging due to unclear mechanisms. Propionate is increasingly seen as critical to sepsis pathophysiology by bridging gut microbiota and immunity, but the mechanisms remain unclear. Our study analysed differences in propionate metabolism in peripheral blood mon...

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Bibliographic Details

Published in:	Scientific Reports
Main Authors:	Lechen Yang, Weifeng Shang, Dongjie Chen, Hang Qian, Sheng Zhang, Xiaojun Pan, Sisi Huang, Jiao Liu, Dechang Chen
Format:	Article
Language:	English
Published:	Nature Portfolio 2025-07-01
Subjects:	Sepsis Propionate metabolism Plasma cells Machine learning Diagnostic modeling
Online Access:	https://doi.org/10.1038/s41598-025-06463-2