BAK/BAX-Mediated Apoptosis Is a Myc-Induced Roadblock to Reprogramming

Summary: Despite intensive efforts to optimize the process, reprogramming differentiated cells to induced pluripotent stem cells (iPSCs) remains inefficient. The most common combination of transcription factors employed comprises OCT4, KLF4, SOX2, and MYC (OKSM). If MYC is omitted (OKS), reprogrammi...

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Bibliographic Details

Published in:	Stem Cell Reports
Main Authors:	Esther J.Y. Kim, Minna-Liisa Anko, Christoffer Flensberg, Ian J. Majewski, Fan-Suo Geng, Jaber Firas, David C.S. Huang, Mark F. van Delft, Joan K. Heath
Format:	Article
Language:	English
Published:	Elsevier 2018-02-01
Online Access:	http://www.sciencedirect.com/science/article/pii/S2213671117305672