Optineurin deficiency disrupts phosphorylated tau proteostasis and clusterin expression in human neurons

Optineurin (OPTN) is an autophagy adaptor protein involved in selective autophagy, including aggrephagy and mitophagy. Pathogenic mutations in OPTN have also been linked to amyotrophic lateral sclerosis, frontotemporal dementia, and glaucoma, supporting its role in the etiology of neurodegenerative...

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Bibliographic Details

Published in:	Acta Neuropathologica Communications
Main Authors:	Zachary M. Augur, Garrett M. Fogo, Mason R. Arbery, Andrew M. Stern, Courtney R. Benoit, Yi-Chen Hsieh, Tracy L. Young-Pearse
Format:	Article
Language:	English
Published:	BMC 2025-09-01
Subjects:	Optineurin Autophagy Tau Alzheimer’s disease Clusterin
Online Access:	https://doi.org/10.1186/s40478-025-02103-y