Fine-mapping from summary data with the "Sum of Single Effects" model.

In recent work, Wang et al introduced the "Sum of Single Effects" (SuSiE) model, and showed that it provides a simple and efficient approach to fine-mapping genetic variants from individual-level data. Here we present new methods for fitting the SuSiE model to summary data, for example to...

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Bibliographic Details
Published in:PLoS Genetics
Main Authors: Yuxin Zou, Peter Carbonetto, Gao Wang, Matthew Stephens
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2022-07-01
Online Access:https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1010299&type=printable