Sialylation of prion protein controls the rate of prion amplification, the cross-species barrier, the ratio of PrPSc glycoform and prion infectivity.

The central event underlying prion diseases involves conformational change of the cellular form of the prion protein (PrP(C)) into the disease-associated, transmissible form (PrP(Sc)). Pr(PC) is a sialoglycoprotein that contains two conserved N-glycosylation sites. Among the key parameters that cont...

全面介紹

書目詳細資料

發表在:	PLoS Pathogens
Main Authors:	Elizaveta Katorcha, Natallia Makarava, Regina Savtchenko, Alessandra D'Azzo, Ilia V Baskakov
格式:	Article
語言:	英语
出版:	Public Library of Science (PLoS) 2014-09-01
在線閱讀:	https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1004366&type=printable