Effects of Neurogenin 3 Induction on Endocrine Differentiation and Delamination in Adult Human Pancreatic Ductal Organoids

Diabetes mellitus is characterized by the loss of pancreatic insulin-secreting β-cells in the Islets of Langerhans. Understanding the regenerative potential of human islet cells is relevant in the context of putative restoration of islet function after damage and novel islet cell replacement therapi...

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Bibliographic Details

Published in:	Transplant International
Main Authors:	Juri Juksar, Rachel Mijdam, Sabine Bosman, Alexander van Oudenaarden, Françoise Carlotti, Eelco J. P. de Koning
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-04-01
Subjects:	pancreas organoid NEUROG3 delamination differentiation
Online Access:	https://www.frontierspartnerships.org/articles/10.3389/ti.2025.13422/full