Spinal cord dorsal horn sensory gate in preclinical models of chemotherapy-induced painful neuropathy and contact dermatitis chronic itch becomes less leaky with Kcc2 gene expression-enhancing treatments

Low intraneuronal chloride in spinal cord dorsal horn (SCDH) pain relay neurons is of critical relevance for physiological transmission of primary sensory afferents because low intraneuronal chloride dictates GABA-ergic and glycin-ergic neurotransmission to be inhibitory. If neuronal chloride rises...

詳細記述

書誌詳細

出版年:	Frontiers in Molecular Neuroscience
主要な著者:	Michele Yeo, Qiaojuan Zhang, LeAnne Ding, Xiangjun Shen, Yong Chen, Wolfgang Liedtke
フォーマット:	論文
言語:	英語
出版事項:	Frontiers Media S.A. 2022-11-01
主題:	spinal cord dorsal horn Kcc2 = potassium-chloride cotransporter 2 TRPV4 TRPA1 kenpaullone pain
オンライン･アクセス:	https://www.frontiersin.org/articles/10.3389/fnmol.2022.911606/full