Disruption in CYLC1 leads to acrosome detachment, sperm head deformity, and male in/subfertility in humans and mice

The perinuclear theca (PT) is a dense cytoplasmic web encapsulating the sperm nucleus. The physiological roles of PT in sperm biology and the clinical relevance of variants of PT proteins to male infertility are still largely unknown. We reveal that cylicin-1, a major constituent of the PT, is vital...

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出版年:	eLife
主要な著者:	Hui-Juan Jin, Yong Fan, Xiaoyu Yang, Yue Dong, Xiao-Zhen Zhang, Xin-Yan Geng, Zheng Yan, Ling Wu, Meng Ma, Bin Li, Qifeng Lyu, Yun Pan, Mingxi Liu, Yanping Kuang, Su-Ren Chen
フォーマット:	論文
言語:	英語
出版事項:	eLife Sciences Publications Ltd 2024-04-01
主題:	perinuclear theca CYLC1 male infertility sperm head deformity acrosome detachment
オンライン･アクセス:	https://elifesciences.org/articles/95054