Effects of treatment with a carbon monoxide donor and an activator of heme oxygenase 1 on the nociceptive, apoptotic and/or oxidative alterations induced by persistent inflammatory pain in the central nervous system of mice

The activation of heme oxygenase 1 (HO-1)/carbon monoxide (CO) inhibits chronic inflammatory pain, but its role in the central nervous system (CNS) is not entirely known. We evaluated whether the treatment with an HO-1 inducer, cobalt protoporphyrin IX (CoPP), or a CO-releasing molecule, tricarbonyl...

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Bibliographic Details

Published in:	Brain Research Bulletin
Main Authors:	Rafael A. Cazuza, Gerard Batallé, Xue Bai, Christie R.A. Leite-Panissi, Olga Pol
Format:	Article
Language:	English
Published:	Elsevier 2022-10-01
Subjects:	Apoptosis Carbon monoxide Heme oxygenase Inflammatory pain Nociception Oxidative stress
Online Access:	http://www.sciencedirect.com/science/article/pii/S0361923022001952