Regulatory dynamics of Sch9 in response to cytosolic acidification: From spatial reconfiguration to cellular adaptation to stresses

Summary: The regulation of cellular metabolism is crucial for cell survival, with Sch9 in Saccharomyces cerevisiae serving a key role as a substrate of TORC1. Sch9 localizes to the vacuolar membrane through binding to PI(3,5)P2, which is necessary for TORC1-dependent phosphorylation. This study demo...

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Bibliographic Details

Published in:	iScience
Main Authors:	Rui Fujii, Rai Katsukawa, Eigo Takeda, Eisuke Itakura, Akira Matsuura
Format:	Article
Language:	English
Published:	Elsevier 2025-01-01
Subjects:	Cellular physiology Cell biology Functional aspects of cell biology
Online Access:	http://www.sciencedirect.com/science/article/pii/S2589004224028001