Loss of catecholaminergic neuromodulation of persistent forms of hippocampal synaptic plasticity with increasing age

Neuromodulation by means of the catecholaminergic system is a key component of motivation-driven learning and behaviorally modulated hippocampal synaptic plasticity. In particular, dopamine acting on D1/D5 receptors and noradrenaline acting on beta-adrenergic receptors exert a very potent regulation...

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Bibliographic Details

Published in:	Frontiers in Synaptic Neuroscience
Main Authors:	Hannah Twarkowski, Denise Manahan-Vaughan
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2016-09-01
Subjects:	Dentate Gyrus Dopamine Isoproterenol LTP rat synaptic plasticity
Online Access:	http://journal.frontiersin.org/Journal/10.3389/fnsyn.2016.00030/full