Designing combination therapies for cancer treatment: application of a mathematical framework combining CAR T-cell immunotherapy and targeted radionuclide therapy

IntroductionCancer combination treatments involving immunotherapies with targeted radiation therapy are at the forefront of treating cancers. However, dosing and scheduling of these therapies pose a challenge. Mathematical models provide a unique way of optimizing these therapies. MethodsUsing a pre...

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Bibliographic Details

Published in:	Frontiers in Immunology
Main Authors:	Vikram Adhikarla, Dennis Awuah, Enrico Caserta, Megan Minnix, Maxim Kuznetsov, Amrita Krishnan, Jefferey Y. C. Wong, John E. Shively, Xiuli Wang, Flavia Pichiorri, Russell C. Rockne
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2024-04-01
Subjects:	radionuclide combination therapy myeloma CAR T cells daratumumab mathematical model
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2024.1358478/full