The hyaluronan-related genes HAS2, HYAL1-4, PH20 and HYALP1 are associated with prognosis, cell viability and spheroid formation capacity in ovarian cancer

Abstract Purpose Hyaluronan modulates tumour progression, including cell adhesion, cohesion, proliferation and invasion, and the cancer stem cell phenotype. In ovarian cancer, high levels of stromal hyaluronan are associated with poor prognosis. In this work, hyaluronan synthases (HAS1-3) and hyalur...

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Bibliographic Details
Published in:Journal of Cancer Research and Clinical Oncology
Main Authors: Jette Riecks, Arianna Parnigoni, Balázs Győrffy, Ludwig Kiesel, Alberto Passi, Davide Vigetti, Martin Götte
Format: Article
Language:English
Published: Springer 2022-06-01
Subjects:
Ovarian cancer
Hyaluronidases
Hyaluronan synthases
HAS2
Gene expression
Survival analysis
Online Access:https://doi.org/10.1007/s00432-022-04127-6

Internet

https://doi.org/10.1007/s00432-022-04127-6

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