Conformations of Bcs1L undergoing ATP hydrolysis suggest a concerted translocation mechanism for folded iron-sulfur protein substrate

Abstract The human AAA-ATPase Bcs1L translocates the fully assembled Rieske iron-sulfur protein (ISP) precursor across the mitochondrial inner membrane, enabling respiratory Complex III assembly. Exactly how the folded substrate is bound to and released from Bcs1L has been unclear, and there has bee...

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Bibliographic Details

Published in:	Nature Communications
Main Authors:	Jingyu Zhan, Allison Zeher, Rick Huang, Wai Kwan Tang, Lisa M. Jenkins, Di Xia
Format:	Article
Language:	English
Published:	Nature Portfolio 2024-05-01
Online Access:	https://doi.org/10.1038/s41467-024-49029-y