Flufenamic acid-based sulfonohydrazide and acetamide derivatives NSAI as inhibitors of multi-targets COX-1/COX-2/5-LOX: design, synthesis, in silico ADMET and binding mode studies

Abstract Although inflammation triggers immune-mediated healing and repair, chronic inflammation can result in several diseases. Cyclooxygenase (COX) enzymes are inhibited by NSAIDs, which are used to relieve the symptoms of inflammation. Meclofenamic and Zileuton are examples of dual COX/LOX inhibi...

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Bibliographic Details

Published in:	BMC Chemistry
Main Authors:	Shaimaa Hussein, Eman A. Fayed, Ahmed Ragab, Moustafa S. Abusaif, Yousry A. Ammar, Reda El-Sayed Mansou, Arafa Musa, Triveena M. Ramsis
Format:	Article
Language:	English
Published:	BMC 2025-10-01
Subjects:	Flufenamic acid Hybrids NSAID COX-1 and COX-2 5-LOX PGE2
Online Access:	https://doi.org/10.1186/s13065-025-01566-3