eIF5A hypusination, boosted by dietary spermidine, protects from premature brain aging and mitochondrial dysfunction

Summary: Mitochondrial function declines during brain aging and is suspected to play a key role in age-induced cognitive decline and neurodegeneration. Supplementing levels of spermidine, a body-endogenous metabolite, has been shown to promote mitochondrial respiration and delay aspects of brain agi...

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書誌詳細

出版年:	Cell Reports
主要な著者:	YongTian Liang, Chengji Piao, Christine B. Beuschel, David Toppe, Laxmikanth Kollipara, Boris Bogdanow, Marta Maglione, Janine Lützkendorf, Jason Chun Kit See, Sheng Huang, Tim O.F. Conrad, Ulrich Kintscher, Frank Madeo, Fan Liu, Albert Sickmann, Stephan J. Sigrist
フォーマット:	論文
言語:	英語
出版事項:	Elsevier 2021-04-01
主題:	eIF5A hypusination spermidine CG8005 deoxyhypusine synthase eIF5A brain aging
オンライン･アクセス:	http://www.sciencedirect.com/science/article/pii/S2211124721002552