LRRK2-mediated neurodegeneration and dysfunction of dopaminergic neurons in a Caenorhabditis elegans model of Parkinson's disease

Mutations in LRRK2 are thus far the most frequent known cause of autosomal dominant and idiopathic Parkinson's disease (PD) with prevalent mutations being found within the GTPase (R1441C/G) and kinase (G2019S) domains. Previous in vitro studies have revealed that R1441C and G2019S mutations are...

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الحاوية / القاعدة:	Neurobiology of Disease
المؤلفون الرئيسيون:	Chen Yao, Rabih El Khoury, Wen Wang, Tara A. Byrd, Elizabeth A. Pehek, Colin Thacker, Xiongwei Zhu, Mark A. Smith, Amy L. Wilson-Delfosse, Shu G. Chen
التنسيق:	مقال
اللغة:	الإنجليزية
منشور في:	Elsevier 2010-10-01
الموضوعات:	Leucine-rich repeat kinase 2 Parkinson's disease Caenorhabditis elegans Dopamine Neurodegeneration
الوصول للمادة أونلاين:	http://www.sciencedirect.com/science/article/pii/S0969996110000999