USP19 deubiquitinase inactivation regulates α-synuclein ubiquitination and inhibits accumulation of Lewy body-like aggregates in mice

Abstract The USP19 deubiquitinase is found in a locus associated with Parkinson’s Disease (PD), interacts with chaperonins, and promotes secretion of α-synuclein (α-syn) through the misfolding-associated protein secretion (MAPS) pathway. Since these processes might modulate the processing of α-syn a...

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Bibliographic Details

Published in:	npj Parkinson's Disease
Main Authors:	Lenka Schorova, Nathalie Bedard, Anouar Khayachi, Hung-Hsiang Ho, Joao Bolivar-Pedroso, Julie Huynh, Mikaela Piccirelli, Yifei Wang, Marie Plourde, Wen Luo, Esther del Cid-Pellitero, Irina Shlaifer, María José Castellanos-Montiel, Ziqi Yu, Dulce Valeria Carrillo Valenzuela, María Lacalle-Aurioles, Anita Kriz, Yihong Ye, Thomas M. Durcan, Simon S. Wing
Format:	Article
Language:	English
Published:	Nature Portfolio 2023-11-01
Online Access:	https://doi.org/10.1038/s41531-023-00601-1