Dexamethasone attenuates interferon-related cytokine hyperresponsiveness in COVID-19 patients

BackgroundDexamethasone improves the survival of COVID-19 patients in need of supplemental oxygen therapy. Although its broad immunosuppressive effects are well-described, the immunological mechanisms modulated by dexamethasone in patients hospitalized with COVID-19 remain to be elucidated.Objective...

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Bibliographic Details

Published in:	Frontiers in Immunology
Main Authors:	Job J. Engel, Caspar I. van der Made, Nick Keur, Todia Setiabudiawan, Rutger J. Röring, Georgia Damoraki, Helga Dijkstra, Heidi Lemmers, Sofia Ioannou, Garyfallia Poulakou, Jos W. M. van der Meer, Evangelos J. Giamarellos-Bourboulis, Vinod Kumar, Frank L. van de Veerdonk, Mihai G. Netea, Athanasios Ziogas
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2023-08-01
Subjects:	COVID-19 SARS-CoV-2 dexamethasone cytokine storm interferon ISG15
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2023.1233318/full