PF-114, a Novel Inhibitor of Bcr-Abl Chimeric Tyrosine Kinase, Attenuates Intracellular CrkL Phosphorylation and Kills Chronic Myeloid Leukemia Cells

Background & Aims. The chimeric tyrosine kinase Bcr-Abl triggers malignant transformation of myeloid cells via phosphorylation of a number of substrates including the CrkL adaptor protein. Pharmacological inhibition of Bcr-Abl mediated signaling is a major strategy in treatment of patients with...

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Bibliographic Details

Published in:	Клиническая онкогематология
Main Authors:	ES Kolotova, VV Tatarskii, AA Zeifman, OV Stroganov, VS Stroilov, IYu Titov, FN Novikov, AA Kalinina, GG Chilov, AA Shtil’
Format:	Article
Language:	Russian
Published:	Practical Medicine Publishing House 2016-01-01
Subjects:	chronic myeloid leukemia Bcr-Abl tyrosine kinase protein phosphorylation flow cytometry cytotoxicity
Online Access:	http://bloodjournal.ru/en/pf-114-a-novel-inhibitor-of-bcr-abl-chimeric-tyrosine-kinase-attenuates-intracellular-crkl-phosphorylation-and-kills-chronic-myeloid-leukemia-cells/